GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs59374417 | 1 | rs12487430 | chr3:119291791 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |
| BRCA | cis | rs9876781 | 1 | rs12487542 | chr3:48426076 | TREX1 | chr3:48501186-48509043:+ | -0.27 | -10.18 | 2.77E-23 | Longevity |
| BRCA | cis | rs9847710 | 1 | rs12488768 | chr3:53086234 | ITIH4 | chr3:52847007-52866554:- | 0.11 | 3.87 | 0.000116 | Ulcerative colitis |
| BRCA | cis | rs59374417 | 1 | rs12489080 | chr3:119293183 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |
| BRCA | cis | rs12636651 | 1 | rs12489891 | chr3:46310518 | TDGF1 | chr3:46619180-46623950:+ | 0.14 | 3.84 | 0.000133 | Obesity-related traits;Monocyte chemoattractant protein-1 |
| BRCA | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | ANAPC13 | chr3:134196547-134204865:- | 0.43 | 14.44 | 2.78E-43 | Height |
| BRCA | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | CEP63 | chr3:134204575-134293852:+ | 0.15 | 4.04 | 5.82E-5 | Height |
| BRCA | cis | rs6774280 | 1 | rs12495108 | chr3:6254653 | GRM7 | chr3:6902802-7783218:+ | 0.16 | 3.9 | 0.000101 | Response to tocilizumab in rheumatoid arthritis |
| BRCA | cis | rs59374417 | 1 | rs12496520 | chr3:119294316 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |
| BRCA | cis | rs7665090 | 1 | rs12498722 | chr4:103554522 | MANBA | chr4:103552644-103682151:- | 0.21 | 5.4 | 8.35E-8 | Primary biliary cirrhosis |
| BRCA | cis | rs4691139 | 1 | rs12498808 | chr4:165906905 | TRIM61 | chr4:165875600-165898818:- | 0.25 | 8.1 | 1.44E-15 | Ovarian cancer in BRCA1 mutation carriers |
| BRCA | cis | rs1061377 | 1 | rs12499266 | chr4:39119753 | KLHL5 | chr4:39046659-39123828:+ | 0.16 | 5.09 | 4.18E-7 | Uric acid levels |
| BRCA | cis | rs7692995 | 1 | rs12503997 | chr4:17948089 | NCAPG | chr4:17812525-17846485:+ | -0.08 | -3.8 | 0.00015 | Height |
| BRCA | cis | rs12505749 | 1 | rs12505749 | chr4:57334112 | SRP72 | chr4:57333762-57369846:+ | -0.26 | -4.86 | 1.37E-6 | Airflow obstruction |
| BRCA | cis | rs7692995 | 1 | rs12506752 | chr4:17948352 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.06 | 5.19E-5 | Height |